263420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2446116..2446638 Replicon chromosome
Accession NZ_CP110201
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 1104-65

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag OCK73_RS11940 Protein ID WP_000221343.1
Coordinates 2446354..2446638 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag OCK73_RS11935 Protein ID WP_000885424.1
Coordinates 2446116..2446364 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCK73_RS11910 (2441332) 2441332..2442798 + 1467 WP_000987828.1 hypothetical protein -
OCK73_RS11915 (2443606) 2443606..2444320 + 715 Protein_2330 helix-turn-helix domain-containing protein -
OCK73_RS11920 (2444376) 2444376..2445284 - 909 WP_010989018.1 hypothetical protein -
OCK73_RS11925 (2445427) 2445427..2445759 - 333 WP_000253154.1 DUF1493 family protein -
OCK73_RS11930 (2445749) 2445749..2445964 - 216 WP_000206207.1 hypothetical protein -
OCK73_RS11935 (2446116) 2446116..2446364 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCK73_RS11940 (2446354) 2446354..2446638 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCK73_RS11945 (2446809) 2446809..2447198 + 390 WP_000194089.1 RidA family protein -
OCK73_RS11950 (2447250) 2447250..2448329 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
OCK73_RS11955 (2448522) 2448522..2449010 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
OCK73_RS11960 (2449055) 2449055..2450563 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2441335..2453420 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T263420 WP_000221343.1 NZ_CP110201:2446354-2446638 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT263420 WP_000885424.1 NZ_CP110201:2446116-2446364 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References