Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3924350..3924947 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag OEW01_RS19260 Protein ID WP_004893639.1
Coordinates 3924630..3924947 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OEW01_RS19255 Protein ID WP_004142561.1
Coordinates 3924350..3924637 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS19225 (3920557) 3920557..3920805 + 249 WP_002893037.1 DUF1158 domain-containing protein -
OEW01_RS19230 (3920823) 3920823..3921164 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OEW01_RS19235 (3921195) 3921195..3922310 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
OEW01_RS19240 (3922490) 3922490..3923071 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
OEW01_RS19245 (3923071) 3923071..3923439 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
OEW01_RS19250 (3923559) 3923559..3924212 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
OEW01_RS19255 (3924350) 3924350..3924637 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OEW01_RS19260 (3924630) 3924630..3924947 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEW01_RS19265 (3925132) 3925132..3926175 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
OEW01_RS19270 (3926845) 3926845..3927711 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
OEW01_RS19275 (3927820) 3927820..3929247 + 1428 WP_105910454.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3924350..3933504 9154


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T263373 WP_004893639.1 NZ_CP110193:c3924947-3924630 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT263373 WP_004142561.1 NZ_CP110193:c3924637-3924350 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References