Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 734841..735616 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OEW01_RS03650 Protein ID WP_004150910.1
Coordinates 735131..735616 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OEW01_RS03645 Protein ID WP_004150912.1
Coordinates 734841..735134 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS03625 (730049) 730049..730651 - 603 WP_002916735.1 short chain dehydrogenase -
OEW01_RS03630 (730749) 730749..731660 + 912 WP_105910473.1 LysR family transcriptional regulator -
OEW01_RS03635 (731661) 731661..732809 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OEW01_RS03640 (732820) 732820..734196 - 1377 WP_004217775.1 cystathionine beta-synthase -
OEW01_RS03645 (734841) 734841..735134 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OEW01_RS03650 (735131) 735131..735616 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OEW01_RS03655 (736320) 736320..736913 + 594 WP_004188553.1 hypothetical protein -
OEW01_RS03660 (737010) 737010..737226 + 217 Protein_719 transposase -
OEW01_RS03665 (737851) 737851..738921 - 1071 WP_045337777.1 ParA family protein -
OEW01_RS03670 (739064) 739064..739402 - 339 WP_045337778.1 hypothetical protein -
OEW01_RS03675 (739427) 739427..739978 - 552 WP_045337779.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 737010..737162 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T263366 WP_004150910.1 NZ_CP110193:735131-735616 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT263366 WP_004150912.1 NZ_CP110193:734841-735134 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References