Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 356223..356869 Replicon chromosome
Accession NZ_CP110193
Organism Klebsiella pneumoniae strain FK563

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag OEW01_RS01655 Protein ID WP_004188313.1
Coordinates 356223..356570 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag OEW01_RS01660 Protein ID WP_004188315.1
Coordinates 356570..356869 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEW01_RS01645 (352149) 352149..353582 + 1434 WP_002920564.1 glycogen synthase GlgA -
OEW01_RS01650 (353600) 353600..356047 + 2448 WP_002920561.1 glycogen phosphorylase -
OEW01_RS01655 (356223) 356223..356570 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEW01_RS01660 (356570) 356570..356869 + 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
OEW01_RS01665 (356932) 356932..358440 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
OEW01_RS01670 (358645) 358645..358974 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
OEW01_RS01675 (359025) 359025..359855 + 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
OEW01_RS01680 (359905) 359905..360663 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T263365 WP_004188313.1 NZ_CP110193:356223-356570 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT263365 WP_004188315.1 NZ_CP110193:356570-356869 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References