Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5771929..5772524 Replicon chromosome
Accession NZ_CP110190
Organism Pseudomonas aeruginosa strain HS204

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OMP51_RS27390 Protein ID WP_003113526.1
Coordinates 5772246..5772524 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OMP51_RS27385 Protein ID WP_003113527.1
Coordinates 5771929..5772234 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMP51_RS27365 (OMP51_27350) 5767322..5767594 - 273 WP_003115921.1 hypothetical protein -
OMP51_RS27370 (OMP51_27355) 5767704..5767970 + 267 WP_023088595.1 hypothetical protein -
OMP51_RS27375 (OMP51_27360) 5768026..5768361 + 336 WP_079862847.1 hypothetical protein -
OMP51_RS27380 (OMP51_27365) 5768476..5770935 - 2460 WP_124089962.1 SIR2 family protein -
OMP51_RS27385 (OMP51_27370) 5771929..5772234 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
OMP51_RS27390 (OMP51_27375) 5772246..5772524 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMP51_RS27395 (OMP51_27380) 5772577..5772705 - 129 Protein_5418 integrase -
OMP51_RS27400 (OMP51_27385) 5772853..5775081 + 2229 WP_028680758.1 TonB-dependent receptor -
OMP51_RS27405 (OMP51_27390) 5775151..5775798 - 648 WP_003095021.1 carbonate dehydratase -
OMP51_RS27410 (OMP51_27395) 5775860..5777098 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T263361 WP_003113526.1 NZ_CP110190:c5772524-5772246 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT263361 WP_003113527.1 NZ_CP110190:c5772234-5771929 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References