263345

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 167..800 Replicon chromosome
Accession NZ_CP110189
Organism Vibrio cholerae strain E1

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag OFY13_RS13590 Protein ID WP_000843587.1
Coordinates 468..800 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OFY13_RS13585 Protein ID WP_000071010.1
Coordinates 167..481 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY13_RS13585 (OFY13_13585) 167..481 - 315 WP_000071010.1 DNA-binding transcriptional regulator Antitoxin
OFY13_RS13590 (OFY13_13590) 468..800 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OFY13_RS13595 (OFY13_13595) 868..979 - 112 Protein_3 DUF3265 domain-containing protein -
OFY13_RS13600 (OFY13_13600) 976..1719 - 744 WP_000188760.1 toll/interleukin-1 receptor domain-containing protein -
OFY13_RS13605 (OFY13_13605) 1877..2824 - 948 WP_000433728.1 HEPN domain-containing protein -
OFY13_RS13610 (OFY13_13610) 2961..3461 - 501 WP_000686368.1 NAD(P)H-dependent oxidoreductase -
OFY13_RS13615 (OFY13_13615) 3715..3951 + 237 WP_000772130.1 RNA-binding protein -
OFY13_RS13620 (OFY13_13620) 4234..5195 + 962 Protein_8 integron integrase IntIA -
OFY13_RS13625 (OFY13_13625) 5277..5630 - 354 WP_001138366.1 50S ribosomal protein L20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 44..1062811 1062767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Antitoxin MqsA/HigA-2

(28-101)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T263345 WP_000843587.1 NZ_CP110189:c800-468 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11687.19 Da        Isoelectric Point: 6.6445

>AT263345 WP_000071010.1 NZ_CP110189:c481-167 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSQIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References