Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 175184..175911 | Replicon | plasmid pYZ22CS094_1 |
| Accession | NZ_CP110168 | ||
| Organism | Klebsiella pneumoniae strain YZ22CS094 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | OK019_RS27260 | Protein ID | WP_011251285.1 |
| Coordinates | 175600..175911 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OK019_RS27255 | Protein ID | WP_011251286.1 |
| Coordinates | 175184..175603 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OK019_RS27240 | 172175..172870 | - | 696 | WP_064160295.1 | molecular chaperone | - |
| OK019_RS27245 | 172929..173498 | - | 570 | WP_064160296.1 | fimbrial protein | - |
| OK019_RS27250 | 174045..175013 | + | 969 | WP_016151349.1 | IS5 family transposase | - |
| OK019_RS27255 | 175184..175603 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| OK019_RS27260 | 175600..175911 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OK019_RS27265 | 176116..176553 | - | 438 | Protein_176 | DDE-type integrase/transposase/recombinase | - |
| OK019_RS27270 | 176667..177005 | + | 339 | WP_023288266.1 | transposase | - |
| OK019_RS27275 | 177002..177349 | + | 348 | WP_032430752.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| OK019_RS27280 | 177398..178936 | + | 1539 | WP_032430751.1 | IS66 family transposase | - |
| OK019_RS27285 | 178976..179155 | + | 180 | Protein_180 | IS5/IS1182 family transposase | - |
| OK019_RS27290 | 179700..180680 | - | 981 | WP_048293850.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 | pla | 1..262096 | 262096 | |
| - | inside | IScluster/Tn | - | - | 174045..180680 | 6635 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T263328 WP_011251285.1 NZ_CP110168:c175911-175600 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT263328 WP_011251286.1 NZ_CP110168:c175603-175184 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|