Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4021486..4022083 Replicon chromosome
Accession NZ_CP110160
Organism Klebsiella pneumoniae strain YZ22CS089

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag OMD38_RS20150 Protein ID WP_004142563.1
Coordinates 4021766..4022083 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OMD38_RS20145 Protein ID WP_004142561.1
Coordinates 4021486..4021773 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD38_RS20115 (4017566) 4017566..4017814 + 249 WP_020325243.1 DUF1158 domain-containing protein -
OMD38_RS20120 (4017832) 4017832..4018173 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OMD38_RS20125 (4018204) 4018204..4019319 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
OMD38_RS20130 (4019499) 4019499..4020080 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
OMD38_RS20135 (4020080) 4020080..4020448 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
OMD38_RS20140 (4020568) 4020568..4021221 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
OMD38_RS20145 (4021486) 4021486..4021773 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OMD38_RS20150 (4021766) 4021766..4022083 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD38_RS20155 (4022268) 4022268..4023311 - 1044 WP_020325241.1 DUF2157 domain-containing protein -
OMD38_RS20160 (4023981) 4023981..4024847 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
OMD38_RS20165 (4024956) 4024956..4026383 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T263303 WP_004142563.1 NZ_CP110160:c4022083-4021766 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT263303 WP_004142561.1 NZ_CP110160:c4021773-4021486 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References