Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 22095..22822 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP110154 | ||
| Organism | Klebsiella pneumoniae strain YZ22CS088 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | OMD36_RS27015 | Protein ID | WP_011251285.1 |
| Coordinates | 22095..22406 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OMD36_RS27020 | Protein ID | WP_011251286.1 |
| Coordinates | 22403..22822 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OMD36_RS26985 | 18052..18483 | - | 432 | WP_131140061.1 | hypothetical protein | - |
| OMD36_RS26990 | 18533..19501 | + | 969 | WP_264870101.1 | IS5 family transposase | - |
| OMD36_RS26995 | 19559..20608 | - | 1050 | Protein_24 | IS66 family transposase | - |
| OMD36_RS27000 | 20657..21004 | - | 348 | WP_130948858.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| OMD36_RS27005 | 21001..21339 | - | 339 | WP_023288266.1 | transposase | - |
| OMD36_RS27010 | 21453..21890 | + | 438 | Protein_27 | DDE-type integrase/transposase/recombinase | - |
| OMD36_RS27015 | 22095..22406 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OMD36_RS27020 | 22403..22822 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| OMD36_RS27025 | 22940..23908 | + | 969 | WP_072193960.1 | IS5 family transposase | - |
| OMD36_RS27030 | 23945..24391 | - | 447 | WP_285806455.1 | hypothetical protein | - |
| OMD36_RS27035 | 24391..24855 | - | 465 | WP_004026319.1 | conjugative transfer protein MobI(A/C) | - |
| OMD36_RS27040 | 25453..26208 | + | 756 | WP_171877782.1 | hypothetical protein | - |
| OMD36_RS27045 | 26401..26925 | + | 525 | WP_117282702.1 | hypothetical protein | - |
| OMD36_RS27050 | 27123..27793 | + | 671 | Protein_35 | IS1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 | - | 1..239545 | 239545 | |
| - | inside | IScluster/Tn | - | - | 18533..38760 | 20227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T263290 WP_011251285.1 NZ_CP110154:22095-22406 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT263290 WP_011251286.1 NZ_CP110154:22403-22822 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|