Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4023513..4024110 Replicon chromosome
Accession NZ_CP110153
Organism Klebsiella pneumoniae strain YZ22CS088

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag OMD36_RS20150 Protein ID WP_004142563.1
Coordinates 4023793..4024110 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OMD36_RS20145 Protein ID WP_004142561.1
Coordinates 4023513..4023800 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD36_RS20115 (4019593) 4019593..4019841 + 249 WP_020325243.1 DUF1158 domain-containing protein -
OMD36_RS20120 (4019859) 4019859..4020200 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OMD36_RS20125 (4020231) 4020231..4021346 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
OMD36_RS20130 (4021526) 4021526..4022107 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
OMD36_RS20135 (4022107) 4022107..4022475 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
OMD36_RS20140 (4022595) 4022595..4023248 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
OMD36_RS20145 (4023513) 4023513..4023800 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OMD36_RS20150 (4023793) 4023793..4024110 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD36_RS20155 (4024295) 4024295..4025338 - 1044 WP_020325241.1 DUF2157 domain-containing protein -
OMD36_RS20160 (4026008) 4026008..4026874 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
OMD36_RS20165 (4026983) 4026983..4028410 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T263283 WP_004142563.1 NZ_CP110153:c4024110-4023793 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT263283 WP_004142561.1 NZ_CP110153:c4023800-4023513 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References