Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 729267..730042 Replicon chromosome
Accession NZ_CP110150
Organism Klebsiella pneumoniae strain YZ22CS072

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OK018_RS03610 Protein ID WP_004150910.1
Coordinates 729557..730042 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OK018_RS03605 Protein ID WP_004150912.1
Coordinates 729267..729560 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK018_RS03585 (724475) 724475..725077 - 603 WP_002916735.1 short chain dehydrogenase -
OK018_RS03590 (725175) 725175..726086 + 912 WP_004188550.1 LysR family transcriptional regulator -
OK018_RS03595 (726087) 726087..727235 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OK018_RS03600 (727246) 727246..728622 - 1377 WP_004217775.1 cystathionine beta-synthase -
OK018_RS03605 (729267) 729267..729560 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OK018_RS03610 (729557) 729557..730042 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OK018_RS03615 (730746) 730746..731339 + 594 WP_004188553.1 hypothetical protein -
OK018_RS03620 (731436) 731436..731652 + 217 Protein_711 transposase -
OK018_RS03625 (732258) 732258..733130 + 873 WP_004188557.1 ParA family protein -
OK018_RS03630 (733130) 733130..733513 + 384 WP_004150906.1 hypothetical protein -
OK018_RS03635 (733506) 733506..734873 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 731436..731588 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T263259 WP_004150910.1 NZ_CP110150:729557-730042 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT263259 WP_004150912.1 NZ_CP110150:729267-729560 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References