Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 28744..29471 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP110147 | ||
| Organism | Klebsiella pneumoniae strain YZ22CK024 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | OMD35_RS27495 | Protein ID | WP_011251285.1 |
| Coordinates | 29160..29471 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OMD35_RS27490 | Protein ID | WP_011251286.1 |
| Coordinates | 28744..29163 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OMD35_RS27475 | 25827..26522 | - | 696 | WP_064160295.1 | molecular chaperone | - |
| OMD35_RS27480 | 26581..27150 | - | 570 | WP_064160296.1 | fimbrial protein | - |
| OMD35_RS27485 | 27605..28573 | + | 969 | WP_016151349.1 | IS5 family transposase | - |
| OMD35_RS27490 | 28744..29163 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| OMD35_RS27495 | 29160..29471 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OMD35_RS27500 | 29676..30113 | - | 438 | Protein_32 | DDE-type integrase/transposase/recombinase | - |
| OMD35_RS27505 | 30227..30565 | + | 339 | WP_023288266.1 | transposase | - |
| OMD35_RS27510 | 30562..30909 | + | 348 | WP_032430752.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| OMD35_RS27515 | 30958..32495 | + | 1538 | Protein_35 | IS66 family transposase | - |
| OMD35_RS27520 | 32535..32714 | + | 180 | Protein_36 | IS5/IS1182 family transposase | - |
| OMD35_RS27525 | 33259..34239 | - | 981 | WP_000019445.1 | IS5-like element ISKpn26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / qacE / aadA2 / dfrA12 / qnrS1 / blaLAP-2 / sul2 / aph(3')-Ia / mph(A) | pla | 1..216138 | 216138 | |
| - | inside | IScluster/Tn | - | - | 27605..34239 | 6634 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T263239 WP_011251285.1 NZ_CP110147:c29471-29160 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT263239 WP_011251286.1 NZ_CP110147:c29163-28744 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|