Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2486811..2487500 Replicon chromosome
Accession NZ_CP110142
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag OMD37_RS12470 Protein ID WP_021469727.1
Coordinates 2486811..2487128 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag OMD37_RS12475 Protein ID WP_020804705.1
Coordinates 2487204..2487500 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS12440 (2482513) 2482513..2483022 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
OMD37_RS12445 (2483032) 2483032..2483958 + 927 WP_032435210.1 amino acid ABC transporter permease -
OMD37_RS12450 (2483942) 2483942..2484721 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
OMD37_RS12455 (2484760) 2484760..2485611 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
OMD37_RS12460 (2485689) 2485689..2486306 + 618 WP_032425015.1 glutathione S-transferase family protein -
OMD37_RS12465 (2486377) 2486377..2486604 + 228 WP_002906690.1 tautomerase PptA -
OMD37_RS12470 (2486811) 2486811..2487128 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD37_RS12475 (2487204) 2487204..2487500 + 297 WP_020804705.1 NadS family protein Antitoxin
OMD37_RS12480 (2487579) 2487579..2488025 + 447 WP_032435212.1 hypothetical protein -
OMD37_RS12485 (2488066) 2488066..2489682 - 1617 WP_004175961.1 carbohydrate porin -
OMD37_RS12490 (2489726) 2489726..2491108 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T263206 WP_021469727.1 NZ_CP110142:2486811-2487128 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT263206 WP_020804705.1 NZ_CP110142:2487204-2487500 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References