Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 461131..461650 Replicon chromosome
Accession NZ_CP110141
Organism Streptococcus suis strain WUSS030

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag NOV96_RS02350 Protein ID WP_002939009.1
Coordinates 461393..461650 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NOV96_RS02345 Protein ID WP_240016561.1
Coordinates 461131..461391 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV96_RS02310 (NOV96_02310) 456437..457249 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
NOV96_RS02315 (NOV96_02315) 457269..458264 + 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NOV96_RS02320 (NOV96_02320) 458432..458569 + 138 WP_002939016.1 50S ribosomal protein L34 -
NOV96_RS02325 (NOV96_02325) 458678..459460 + 783 WP_002939015.1 TatD family hydrolase -
NOV96_RS02330 (NOV96_02330) 459423..460013 + 591 WP_002939014.1 ribonuclease M5 -
NOV96_RS02335 (NOV96_02335) 460006..460596 + 591 WP_240016560.1 hypothetical protein -
NOV96_RS02340 (NOV96_02340) 460600..461055 + 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
NOV96_RS02345 (NOV96_02345) 461131..461391 + 261 WP_240016561.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOV96_RS02350 (NOV96_02350) 461393..461650 + 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
NOV96_RS02355 (NOV96_02355) 461664..462194 + 531 WP_002939008.1 DUF1697 domain-containing protein -
NOV96_RS02360 (NOV96_02360) 462214..463086 + 873 WP_002939007.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NOV96_RS02365 (NOV96_02365) 463289..465019 + 1731 WP_024390921.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T263193 WP_002939009.1 NZ_CP110141:461393-461650 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.41 Da        Isoelectric Point: 6.4707

>AT263193 WP_240016561.1 NZ_CP110141:461131-461391 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTKER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure

References