Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5302485..5303064 Replicon chromosome
Accession NZ_CP110131
Organism Methylorubrum extorquens strain NBC_00036

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OKB92_RS25125 Protein ID WP_265222550.1
Coordinates 5302783..5303064 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1W6RKV4
Locus tag OKB92_RS25120 Protein ID WP_056462529.1
Coordinates 5302485..5302769 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKB92_RS25100 (OKB92_25100) 5297919..5300342 - 2424 WP_265222548.1 phenylalanine--tRNA ligase subunit beta -
OKB92_RS25105 (OKB92_25105) 5300407..5301486 - 1080 WP_015950513.1 phenylalanine--tRNA ligase subunit alpha -
OKB92_RS25110 (OKB92_25110) 5301670..5302035 - 366 WP_003602669.1 50S ribosomal protein L20 -
OKB92_RS25115 (OKB92_25115) 5302088..5302291 - 204 WP_003602670.1 50S ribosomal protein L35 -
OKB92_RS25120 (OKB92_25120) 5302485..5302769 - 285 WP_056462529.1 HigA family addiction module antitoxin Antitoxin
OKB92_RS25125 (OKB92_25125) 5302783..5303064 - 282 WP_265222550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OKB92_RS25130 (OKB92_25130) 5303316..5304449 + 1134 WP_056111700.1 glycosyltransferase family 4 protein -
OKB92_RS25135 (OKB92_25135) 5304608..5306944 + 2337 WP_056111703.1 glycogen debranching N-terminal domain-containing protein -
OKB92_RS25140 (OKB92_25140) 5307136..5307657 - 522 WP_003602674.1 translation initiation factor IF-3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10726.03 Da        Isoelectric Point: 7.8895

>T263189 WP_265222550.1 NZ_CP110131:c5303064-5302783 [Methylorubrum extorquens]
MILSYRNRGTEALDVHGVCHRRWRSFQAAAGRKLDMLNAASVVSDLRSPPGNRLEKLSGDREGQWSIRINDQWRICFRWD
GSGPEDVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10570.11 Da        Isoelectric Point: 7.2787

>AT263189 WP_056462529.1 NZ_CP110131:c5302769-5302485 [Methylorubrum extorquens]
MPRIRSHPGEILLEEYLRPLEMSANALAKAIEVPANRISELLRGRRGMTADTACRLGRFFGTTPEFWMSLQTAHDLSRAV
AEHDYSTLRALESA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1W6RKV4

References