Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3891206..3891747 Replicon chromosome
Accession NZ_CP110117
Organism Escherichia coli strain 2-331

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag OMD12_RS19095 Protein ID WP_000615983.1
Coordinates 3891469..3891747 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag OMD12_RS19090 Protein ID WP_000729703.1
Coordinates 3891206..3891466 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD12_RS19070 (3886881) 3886881..3887666 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
OMD12_RS19075 (3887638) 3887638..3889350 + 1713 Protein_3737 flagellar biosynthesis protein FlhA -
OMD12_RS19080 (3889574) 3889574..3890071 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
OMD12_RS19085 (3890247) 3890247..3890996 - 750 WP_000056849.1 C40 family peptidase -
OMD12_RS19090 (3891206) 3891206..3891466 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
OMD12_RS19095 (3891469) 3891469..3891747 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
OMD12_RS19100 (3891903) 3891903..3892643 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
OMD12_RS19105 (3892614) 3892614..3893381 - 768 WP_000333380.1 class II glutamine amidotransferase -
OMD12_RS19110 (3893587) 3893587..3894165 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3885009..3900289 15280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T263143 WP_000615983.1 NZ_CP110117:3891469-3891747 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT263143 WP_000729703.1 NZ_CP110117:3891206-3891466 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References