Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2549777..2550415 Replicon chromosome
Accession NZ_CP110117
Organism Escherichia coli strain 2-331

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag OMD12_RS12355 Protein ID WP_001447010.1
Coordinates 2550239..2550415 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OMD12_RS12350 Protein ID WP_001270286.1
Coordinates 2549777..2550193 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD12_RS12330 (2544929) 2544929..2545870 - 942 WP_001251304.1 ABC transporter permease -
OMD12_RS12335 (2545871) 2545871..2546884 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
OMD12_RS12340 (2546902) 2546902..2548047 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
OMD12_RS12345 (2548292) 2548292..2549698 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
OMD12_RS12350 (2549777) 2549777..2550193 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
OMD12_RS12355 (2550239) 2550239..2550415 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
OMD12_RS12360 (2550637) 2550637..2550867 + 231 WP_000494244.1 YncJ family protein -
OMD12_RS12365 (2550959) 2550959..2552920 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
OMD12_RS12370 (2552993) 2552993..2553529 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
OMD12_RS12375 (2553621) 2553621..2554796 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2554836..2555984 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T263140 WP_001447010.1 NZ_CP110117:c2550415-2550239 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT263140 WP_001270286.1 NZ_CP110117:c2550193-2549777 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References