Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721920..722613 Replicon chromosome
Accession NZ_CP110117
Organism Escherichia coli strain 2-331

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag OMD12_RS03545 Protein ID WP_000415584.1
Coordinates 721920..722216 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OMD12_RS03550 Protein ID WP_000650107.1
Coordinates 722218..722613 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD12_RS03510 (717008) 717008..717322 - 315 WP_000958598.1 putative quinol monooxygenase -
OMD12_RS03515 (717353) 717353..717934 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OMD12_RS03520 (718253) 718253..718585 + 333 WP_000917685.1 DUF2645 family protein -
OMD12_RS03525 (718631) 718631..719980 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
OMD12_RS03530 (719977) 719977..720636 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
OMD12_RS03535 (720788) 720788..721180 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OMD12_RS03540 (721233) 721233..721715 + 483 WP_000183505.1 GyrI-like domain-containing protein -
OMD12_RS03545 (721920) 721920..722216 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
OMD12_RS03550 (722218) 722218..722613 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OMD12_RS03555 (722746) 722746..724353 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OMD12_RS03560 (724491) 724491..726749 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T263129 WP_000415584.1 NZ_CP110117:721920-722216 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT263129 WP_000650107.1 NZ_CP110117:722218-722613 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References