Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3109383..3109953 Replicon chromosome
Accession NZ_CP110114
Organism Arthrobacter sp. YA7-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OIT41_RS14515 Protein ID WP_241710031.1
Coordinates 3109672..3109953 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIT41_RS14510 Protein ID WP_241710030.1
Coordinates 3109383..3109685 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIT41_RS14485 (OIT41_14485) 3105251..3105457 + 207 WP_078108278.1 hypothetical protein -
OIT41_RS14490 (OIT41_14490) 3105541..3105957 - 417 WP_264636668.1 hypothetical protein -
OIT41_RS14495 (OIT41_14495) 3106115..3107881 - 1767 WP_241710027.1 GNAT family N-acetyltransferase -
OIT41_RS14500 (OIT41_14500) 3107966..3108745 + 780 WP_241710028.1 alpha/beta hydrolase -
OIT41_RS14505 (OIT41_14505) 3108759..3109271 - 513 WP_241710029.1 DUF1877 family protein -
OIT41_RS14510 (OIT41_14510) 3109383..3109685 - 303 WP_241710030.1 HigA family addiction module antitoxin Antitoxin
OIT41_RS14515 (OIT41_14515) 3109672..3109953 - 282 WP_241710031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIT41_RS14520 (OIT41_14520) 3110132..3110824 + 693 WP_241710032.1 histidine phosphatase family protein -
OIT41_RS14525 (OIT41_14525) 3110848..3111402 + 555 WP_241710033.1 DUF3090 domain-containing protein -
OIT41_RS14530 (OIT41_14530) 3111402..3112169 + 768 WP_241710034.1 SCO1664 family protein -
OIT41_RS14535 (OIT41_14535) 3112400..3113140 + 741 WP_241710035.1 hypothetical protein -
OIT41_RS14540 (OIT41_14540) 3113431..3114138 + 708 WP_241710036.1 hypothetical protein -
OIT41_RS14545 (OIT41_14545) 3114254..3114715 + 462 WP_241710037.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10798.20 Da        Isoelectric Point: 8.0409

>T263125 WP_241710031.1 NZ_CP110114:c3109953-3109672 [Arthrobacter sp. YA7-1]
MIRSFGSKDTERLWSREHVASMDSRILRSALRKLRQVGSAESIEDLRVPPGNRLEALKGDRAGPYSIRINDQWRICFRWT
DAGPEEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11011.75 Da        Isoelectric Point: 6.8775

>AT263125 WP_241710030.1 NZ_CP110114:c3109685-3109383 [Arthrobacter sp. YA7-1]
MTTIDYLAPIHPGEVLMEDFIVGFGITQNKLAVAIHVPPRRINEIVHGKRAITADTALRLGKYFGTSAQFWLNLQTHYDL
DVAEDRAAGQIAAITPLKIA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References