Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1324836..1325496 Replicon chromosome
Accession NZ_CP110102
Organism Serratia marcescens strain SARVS06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OKB57_RS06250 Protein ID WP_118891868.1
Coordinates 1324836..1325189 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6G8TPX9
Locus tag OKB57_RS06255 Protein ID WP_004935502.1
Coordinates 1325194..1325496 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKB57_RS06230 (OKB57_06230) 1320939..1321304 + 366 WP_004935528.1 diacylglycerol kinase -
OKB57_RS06235 (OKB57_06235) 1321397..1322296 + 900 WP_075686404.1 LysR family transcriptional regulator -
OKB57_RS06240 (OKB57_06240) 1322271..1323077 - 807 WP_118891867.1 substrate-binding domain-containing protein -
OKB57_RS06245 (OKB57_06245) 1323104..1324399 - 1296 WP_004935508.1 MFS transporter -
OKB57_RS06250 (OKB57_06250) 1324836..1325189 + 354 WP_118891868.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OKB57_RS06255 (OKB57_06255) 1325194..1325496 + 303 WP_004935502.1 XRE family transcriptional regulator Antitoxin
OKB57_RS06260 (OKB57_06260) 1325619..1326527 - 909 WP_004935498.1 LysR family transcriptional regulator -
OKB57_RS06265 (OKB57_06265) 1326666..1327586 + 921 WP_031300707.1 alpha/beta hydrolase -
OKB57_RS06270 (OKB57_06270) 1327586..1328521 + 936 WP_088381766.1 alpha/beta hydrolase -
OKB57_RS06275 (OKB57_06275) 1328537..1329172 + 636 WP_015378474.1 SDR family oxidoreductase -
OKB57_RS06280 (OKB57_06280) 1329215..1329943 + 729 WP_226882923.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1315913..1332700 16787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13575.59 Da        Isoelectric Point: 9.0493

>T263110 WP_118891868.1 NZ_CP110102:1324836-1325189 [Serratia marcescens]
VWEIKTTDAFDHWLRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11142.96 Da        Isoelectric Point: 5.1992

>AT263110 WP_004935502.1 NZ_CP110102:1325194-1325496 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G8TPX9

References