Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 136891..137585 Replicon chromosome
Accession NC_017168
Organism Yersinia pestis A1122

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag A1122_RS00595 Protein ID WP_002214787.1
Coordinates 136891..137187 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag A1122_RS00600 Protein ID WP_002209924.1
Coordinates 137187..137585 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1122_RS00560 132013..133530 + 1518 WP_002209930.1 lysine--tRNA ligase -
A1122_RS00570 133963..135177 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
A1122_RS00575 135259..135444 - 186 WP_002209928.1 hypothetical protein -
A1122_RS00585 136042..136302 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1122_RS00590 136365..136727 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
A1122_RS00595 136891..137187 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
A1122_RS00600 137187..137585 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
A1122_RS00605 137985..140276 - 2292 WP_002209923.1 toprim domain-containing protein -
A1122_RS00610 140576..140902 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
A1122_RS23950 140895..141047 + 153 WP_002209921.1 hypothetical protein -
A1122_RS00620 141061..141261 - 201 WP_002209920.1 AlpA family transcriptional regulator -
A1122_RS00625 141443..141775 - 333 WP_002214791.1 hypothetical protein -
A1122_RS00630 141781..142017 - 237 WP_002214792.1 hypothetical protein -
A1122_RS00635 142030..142395 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T26311 WP_002214787.1 NC_017168:136891-137187 [Yersinia pestis A1122]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T26311 NC_017168:136891-137187 [Yersinia pestis A1122]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT26311 WP_002209924.1 NC_017168:137187-137585 [Yersinia pestis A1122]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT26311 NC_017168:137187-137585 [Yersinia pestis A1122]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References