Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 574024..574676 Replicon chromosome
Accession NZ_CP110102
Organism Serratia marcescens strain SARVS06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OKB57_RS02750 Protein ID WP_004931830.1
Coordinates 574332..574676 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag OKB57_RS02745 Protein ID WP_004931828.1
Coordinates 574024..574326 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKB57_RS02720 (OKB57_02720) 569031..569678 - 648 WP_015378930.1 DsbA family protein -
OKB57_RS02725 (OKB57_02725) 569747..570631 - 885 WP_004931820.1 MBL fold metallo-hydrolase -
OKB57_RS02730 (OKB57_02730) 570740..571648 + 909 WP_015378928.1 LysR family transcriptional regulator -
OKB57_RS02735 (OKB57_02735) 571676..572599 - 924 WP_099982443.1 LysR family transcriptional regulator -
OKB57_RS02740 (OKB57_02740) 572734..573996 + 1263 WP_004931826.1 diaminopimelate decarboxylase -
OKB57_RS02745 (OKB57_02745) 574024..574326 - 303 WP_004931828.1 XRE family transcriptional regulator Antitoxin
OKB57_RS02750 (OKB57_02750) 574332..574676 - 345 WP_004931830.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OKB57_RS02755 (OKB57_02755) 574836..575855 - 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
OKB57_RS02760 (OKB57_02760) 576077..578334 + 2258 Protein_539 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13383.44 Da        Isoelectric Point: 10.6087

>T263108 WP_004931830.1 NZ_CP110102:c574676-574332 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT263108 WP_004931828.1 NZ_CP110102:c574326-574024 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References