Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4454137..4454788 Replicon chromosome
Accession NZ_CP110080
Organism Buttiauxella sp. WJP83

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OH773_RS20560 Protein ID WP_270145988.1
Coordinates 4454137..4454487 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OH773_RS20565 Protein ID WP_270141475.1
Coordinates 4454489..4454788 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH773_RS20540 (OH773_20540) 4449286..4450041 - 756 WP_183273132.1 bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE -
OH773_RS20545 (OH773_20545) 4450134..4451543 - 1410 WP_270141471.1 DNA recombination protein RmuC -
OH773_RS20550 (OH773_20550) 4451678..4452439 - 762 WP_183273130.1 uridine phosphorylase -
OH773_RS20555 (OH773_20555) 4452677..4453504 + 828 WP_270141473.1 dienelactone hydrolase family protein -
OH773_RS20560 (OH773_20560) 4454137..4454487 + 351 WP_270145988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OH773_RS20565 (OH773_20565) 4454489..4454788 + 300 WP_270141475.1 helix-turn-helix transcriptional regulator Antitoxin
OH773_RS20570 (OH773_20570) 4454829..4457090 - 2262 WP_270141477.1 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase -
OH773_RS20575 (OH773_20575) 4457210..4458163 + 954 WP_270141479.1 HTH-type transcriptional regulator MetR -
OH773_RS20580 (OH773_20580) 4458051..4458950 - 900 WP_270141482.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13299.40 Da        Isoelectric Point: 6.2252

>T263095 WP_270145988.1 NZ_CP110080:4454137-4454487 [Buttiauxella sp. WJP83]
MWEVITTDVFDRWFLAQANALREDVLAVMGILEEMGPQLGRPYVDTLNGSAFPNMKELRIQHAGVPVRAFFAFDPVRRAI
VLCAGDKTGLNEKQFYRDMIRLAESEYCKHLAHLEK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11047.78 Da        Isoelectric Point: 8.5283

>AT263095 WP_270141475.1 NZ_CP110080:4454489-4454788 [Buttiauxella sp. WJP83]
MSTYKKLLAKQSPESQQEIADKIQVLRQEIALSQLREELKMSQTELAQAVGVSQPTIAKMENPENDPRLSTLKRYVAALG
GELSIDITLPTGKRVVFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References