Detailed information of TA system TA263078

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2789482..2789819
• Replicon: chromosome
• Accession: NZ_CP110074
• Organism: Enterococcus faecalis strain BE5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: OLM06_RS13795
• Protein ID: WP_002381035.1
• Coordinates: 2789482..2789625 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2789557..2789819 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM06_RS13775	2785574..2786212	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
OLM06_RS13780	2786898..2788514	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
OLM06_RS13785	2788843..2788992	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
OLM06_RS13790	2789111..2789251	+	141	WP_073340360.1	putative holin-like toxin	-
OLM06_RS13795	2789482..2789625	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	2789557..2789819	-	263	-	-	Antitoxin
OLM06_RS13800	2789820..2793647	-	3828	WP_010816211.1	WxL domain-containing protein	-
OLM06_RS13805	2793634..2793996	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T263078 WP_002381035.1 NZ_CP110074:2789482-2789625 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT263078 NZ_CP110074:c2789819-2789557 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin