Detailed information of TA system TA263072

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2788925..2789251
• Replicon: chromosome
• Accession: NZ_CP110074
• Organism: Enterococcus faecalis strain BE5

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: OLM06_RS13790
• Protein ID: WP_073340360.1
• Coordinates: 2789111..2789251 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2788925..2789109 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM06_RS13765	2783964..2784179	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
OLM06_RS13770	2784318..2785310	+	993	WP_002389493.1	biotin--[acetyl-CoA-carboxylase] ligase	-
OLM06_RS13775	2785574..2786212	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
OLM06_RS13780	2786898..2788514	+	1617	WP_002389442.1	phosphatase PAP2/LCP family protein	-
OLM06_RS13785	2788843..2788992	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
-	2788925..2789109	-	185	-	-	Antitoxin
OLM06_RS13790	2789111..2789251	+	141	WP_073340360.1	putative holin-like toxin	Toxin
OLM06_RS13795	2789482..2789625	+	144	WP_002381035.1	putative holin-like toxin	-
OLM06_RS13800	2789820..2793647	-	3828	WP_010816211.1	WxL domain-containing protein	-
OLM06_RS13805	2793634..2793996	-	363	WP_002378868.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T263072 WP_073340360.1 NZ_CP110074:2789111-2789251 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT263072 NZ_CP110074:c2789109-2788925 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin