Detailed information of TA system TA026307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1744..2402
• Replicon: plasmid ABKp1
• Accession: NC_017163
• Organism: Acinetobacter baumannii 1656-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ABK1_RS18930
• Protein ID: WP_000312250.1
• Coordinates: 2043..2402 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ABK1_RS18925
• Protein ID: WP_001096429.1
• Coordinates: 1744..2043 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABK1_RS18915	805..1287	+	483	WP_001052677.1	hypothetical protein	-
ABK1_RS18920	1380..1643	-	264	WP_000110863.1	hypothetical protein	-
ABK1_RS18925	1744..2043	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
ABK1_RS18930	2043..2402	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABK1_RS18935	2603..3169	+	567	WP_041171756.1	hypothetical protein	-
ABK1_RS18940	3218..3400	+	183	WP_000373385.1	hypothetical protein	-
ABK1_RS18945	3467..4165	+	699	WP_000873190.1	hypothetical protein	-
ABK1_RS18950	4304..4687	+	384	WP_000654349.1	hypothetical protein	-
ABK1_RS18955	4754..5512	+	759	WP_001053129.1	hypothetical protein	-
ABK1_RS18960	6582..6896	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74451	74451

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T26307 WP_000312250.1 NC_017163:c2402-2043 [Acinetobacter baumannii 1656-2]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T26307 NC_017163:c2402-2043 [Acinetobacter baumannii 1656-2]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT26307 WP_001096429.1 NC_017163:c2043-1744 [Acinetobacter baumannii 1656-2]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT26307 NC_017163:c2043-1744 [Acinetobacter baumannii 1656-2]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA