Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 259619..259956 Replicon chromosome
Accession NZ_CP110071
Organism Enterococcus faecalis strain BE8

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag OLL94_RS01220 Protein ID WP_002396786.1
Coordinates 259813..259956 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 259619..259881 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL94_RS01215 254927..259618 + 4692 WP_002378865.1 WxL domain-containing protein -
- 259619..259881 + 263 - - Antitoxin
OLL94_RS01220 259813..259956 - 144 WP_002396786.1 putative holin-like toxin Toxin
OLL94_RS01225 260288..261904 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
OLL94_RS01230 262589..263227 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
OLL94_RS01235 263394..264386 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLL94_RS01240 264525..264740 + 216 WP_002354768.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T263025 WP_002396786.1 NZ_CP110071:c259956-259813 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT263025 NZ_CP110071:259619-259881 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References