Detailed information of TA system TA263019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2815296..2815632
• Replicon: chromosome
• Accession: NZ_CP110069
• Organism: Enterococcus faecalis strain BE11

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A125WAU0
• Locus tag: OLL93_RS13670
• Protein ID: WP_002391551.1
• Coordinates: 2815296..2815439 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2815583..2815632 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL93_RS13650	2811012..2811644	-	633	WP_002358972.1	RloB family protein	-
OLL93_RS13655	2811653..2812948	-	1296	WP_002371641.1	ATP-binding protein	-
OLL93_RS13660	2812974..2813108	-	135	WP_002391552.1	hypothetical protein	-
OLL93_RS13665	2813410..2815026	+	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
OLL93_RS13670	2815296..2815439	+	144	WP_002391551.1	putative holin-like toxin	Toxin
-	2815583..2815632	+	50	-	-	Antitoxin
OLL93_RS13675	2815634..2820325	-	4692	WP_002399468.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5175.17 Da
• Isoelectric Point: 8.6389

>T263019 WP_002391551.1 NZ_CP110069:2815296-2815439 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 50 bp

>AT263019 NZ_CP110069:2815583-2815632 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A125WAU0

Antitoxin