Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2815296..2815633 Replicon chromosome
Accession NZ_CP110069
Organism Enterococcus faecalis strain BE11

Toxin (Protein)


Gene name txpA Uniprot ID A0A125WAU0
Locus tag OLL93_RS13670 Protein ID WP_002391551.1
Coordinates 2815296..2815439 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2815371..2815633 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL93_RS13650 2811012..2811644 - 633 WP_002358972.1 RloB family protein -
OLL93_RS13655 2811653..2812948 - 1296 WP_002371641.1 ATP-binding protein -
OLL93_RS13660 2812974..2813108 - 135 WP_002391552.1 hypothetical protein -
OLL93_RS13665 2813410..2815026 + 1617 WP_002365430.1 phosphatase PAP2/LCP family protein -
OLL93_RS13670 2815296..2815439 + 144 WP_002391551.1 putative holin-like toxin Toxin
- 2815371..2815633 - 263 - - Antitoxin
OLL93_RS13675 2815634..2820325 - 4692 WP_002399468.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5175.17 Da        Isoelectric Point: 8.6389

>T263017 WP_002391551.1 NZ_CP110069:2815296-2815439 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT263017 NZ_CP110069:c2815633-2815371 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125WAU0

Antitoxin

Download structure file

References