Detailed information of TA system TA263012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2647054..2647538
• Replicon: chromosome
• Accession: NZ_CP110069
• Organism: Enterococcus faecalis strain BE11

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLL93_RS12870
• Protein ID: WP_075551663.1
• Coordinates: 2647054..2647155 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2647329..2647538 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL93_RS12845	2642579..2643532	-	954	WP_264522659.1	siderophore ABC transporter substrate-binding protein	-
OLL93_RS12850	2643571..2644326	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OLL93_RS12855	2644323..2645288	-	966	WP_002365351.1	iron chelate uptake ABC transporter family permease subunit	-
OLL93_RS12860	2645285..2646232	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
OLL93_RS12865	2646417..2646869	+	453	WP_002354958.1	YueI family protein	-
OLL93_RS12870	2647054..2647155	-	102	WP_075551663.1	putative holin-like toxin	Toxin
-	2647329..2647538	+	210	-	-	Antitoxin
OLL93_RS12875	2647487..2647588	-	102	WP_075551663.1	putative holin-like toxin	-
OLL93_RS12880	2647777..2650047	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OLL93_RS12885	2650218..2650718	+	501	WP_002365352.1	cysteine hydrolase family protein	-
OLL93_RS12890	2651117..2652013	+	897	WP_002365354.1	YitT family protein	-
OLL93_RS12895	2652064..2652462	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	2639637..2688562	48925

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T263012 WP_075551663.1 NZ_CP110069:c2647155-2647054 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT263012 NZ_CP110069:2647329-2647538 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin