Detailed information of TA system TA262993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2737895..2738152
• Replicon: chromosome
• Accession: NZ_CP110068
• Organism: Enterococcus faecalis strain BE13

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLM02_RS13435
• Protein ID: WP_075551663.1
• Coordinates: 2738051..2738152 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2737895..2738102 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM02_RS13410	2733579..2734532	-	954	WP_010821905.1	siderophore ABC transporter substrate-binding protein	-
OLM02_RS13415	2734571..2735326	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OLM02_RS13420	2735323..2736288	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
OLM02_RS13425	2736285..2737232	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
OLM02_RS13430	2737417..2737869	+	453	WP_002359057.1	YueI family protein	-
-	2737895..2738102	+	208	-	-	Antitoxin
OLM02_RS13435	2738051..2738152	-	102	WP_075551663.1	putative holin-like toxin	Toxin
OLM02_RS13440	2738341..2740611	-	2271	WP_010821906.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OLM02_RS13445	2740782..2741288	+	507	WP_002406481.1	cysteine hydrolase family protein	-
OLM02_RS13450	2741478..2742374	+	897	WP_002354953.1	YitT family protein	-
OLM02_RS13455	2742425..2742823	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T262993 WP_075551663.1 NZ_CP110068:c2738152-2738051 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT262993 NZ_CP110068:2737895-2738102 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin