Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2815744..2816070 Replicon chromosome
Accession NZ_CP110063
Organism Enterococcus faecalis strain BE15

Toxin (Protein)


Gene name txpA Uniprot ID A0A3N3Z2N6
Locus tag OLL96_RS13790 Protein ID WP_073340360.1
Coordinates 2815930..2816070 (+) Length 47 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2815744..2815928 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL96_RS13765 2810783..2810998 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
OLL96_RS13770 2811137..2812129 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
OLL96_RS13775 2812393..2813031 - 639 WP_073438309.1 lytic polysaccharide monooxygenase -
OLL96_RS13780 2813717..2815333 + 1617 WP_002406969.1 phosphatase PAP2/LCP family protein -
OLL96_RS13785 2815662..2815811 + 150 WP_002411240.1 type I toxin-antitoxin system toxin PepG1 -
- 2815744..2815928 - 185 - - Antitoxin
OLL96_RS13790 2815930..2816070 + 141 WP_073340360.1 putative holin-like toxin Toxin
OLL96_RS13795 2816301..2816444 + 144 WP_073437820.1 putative holin-like toxin -
OLL96_RS13800 2816577..2817536 + 960 WP_002360751.1 IS30-like element IS1062 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2816577..2817536 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-46)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5218.33 Da        Isoelectric Point: 10.3265

>T262976 WP_073340360.1 NZ_CP110063:2815930-2816070 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 141 bp

Antitoxin


Download         Length: 185 bp

>AT262976 NZ_CP110063:c2815928-2815744 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N3Z2N6

Antitoxin

Download structure file

References