Detailed information of TA system TA262955

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2759782..2760119
• Replicon: chromosome
• Accession: NZ_CP110059
• Organism: Enterococcus faecalis strain BE16

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: OLL92_RS13455
• Protein ID: WP_002381035.1
• Coordinates: 2759782..2759925 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2759857..2760119 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL92_RS13430 (2754799)	2754799..2755431	-	633	WP_002358972.1	RloB family protein	-
OLL92_RS13435 (2755440)	2755440..2756735	-	1296	WP_010820355.1	ATP-binding protein	-
OLL92_RS13440 (2757197)	2757197..2758813	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
OLL92_RS13445 (2759143)	2759143..2759292	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2759225)	2759225..2759409	-	185	NuclAT_5	-	-
- (2759266)	2759266..2759409	-	144	NuclAT_7	-	-
OLL92_RS13450 (2759411)	2759411..2759551	+	141	WP_104875700.1	putative holin-like toxin	-
- (2759484)	2759484..2759685	-	202	NuclAT_4	-	-
OLL92_RS13455 (2759782)	2759782..2759925	+	144	WP_002381035.1	putative holin-like toxin	Toxin
- (2760069)	2760069..2760118	+	50	NuclAT_8	-	-
- (2759857)	2759857..2760119	-	263	NuclAT_6	-	Antitoxin
OLL92_RS13460 (2760120)	2760120..2763053	-	2934	WP_264547767.1	WxL domain-containing protein	-
OLL92_RS13465 (2763040)	2763040..2763402	-	363	WP_002370158.1	LPXTG cell wall anchor domain-containing protein	-
OLL92_RS13470 (2763789)	2763789..2764736	-	948	WP_002358958.1	1,4-dihydroxy-2-naphthoate polyprenyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T262955 WP_002381035.1 NZ_CP110059:2759782-2759925 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT262955 NZ_CP110059:c2760119-2759857 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin