Detailed information of TA system TA262932

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2759717..2760054
• Replicon: chromosome
• Accession: NZ_CP110054
• Organism: Enterococcus faecalis strain BE17

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: OLL95_RS13455
• Protein ID: WP_002381035.1
• Coordinates: 2759717..2759860 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2759792..2760054 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL95_RS13430 (2754734)	2754734..2755366	-	633	WP_002358972.1	RloB family protein	-
OLL95_RS13435 (2755375)	2755375..2756670	-	1296	WP_010820355.1	ATP-binding protein	-
OLL95_RS13440 (2757132)	2757132..2758748	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
OLL95_RS13445 (2759078)	2759078..2759227	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	-
- (2759160)	2759160..2759344	-	185	NuclAT_5	-	-
- (2759201)	2759201..2759344	-	144	NuclAT_7	-	-
OLL95_RS13450 (2759346)	2759346..2759486	+	141	WP_104875700.1	putative holin-like toxin	-
- (2759419)	2759419..2759620	-	202	NuclAT_4	-	-
OLL95_RS13455 (2759717)	2759717..2759860	+	144	WP_002381035.1	putative holin-like toxin	Toxin
- (2760004)	2760004..2760053	+	50	NuclAT_8	-	-
- (2759792)	2759792..2760054	-	263	NuclAT_6	-	Antitoxin
OLL95_RS13460 (2760055)	2760055..2762988	-	2934	WP_264547767.1	WxL domain-containing protein	-
OLL95_RS13465 (2762975)	2762975..2763337	-	363	WP_002370158.1	LPXTG cell wall anchor domain-containing protein	-
OLL95_RS13470 (2763724)	2763724..2764671	-	948	WP_002358958.1	1,4-dihydroxy-2-naphthoate polyprenyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T262932 WP_002381035.1 NZ_CP110054:2759717-2759860 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT262932 NZ_CP110054:c2760054-2759792 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin