Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1027659..1028353 Replicon chromosome
Accession NC_017154
Organism Yersinia pestis D106004

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPD4_RS04615 Protein ID WP_002214787.1
Coordinates 1027659..1027955 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPD4_RS04620 Protein ID WP_002209924.1
Coordinates 1027955..1028353 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPD4_RS04580 1022781..1024298 + 1518 WP_002209930.1 lysine--tRNA ligase -
YPD4_RS04590 1024731..1025945 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
YPD4_RS04595 1026027..1026212 - 186 WP_002209928.1 hypothetical protein -
YPD4_RS04605 1026810..1027070 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPD4_RS04610 1027133..1027495 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPD4_RS04615 1027659..1027955 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPD4_RS04620 1027955..1028353 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPD4_RS04625 1028753..1031044 - 2292 WP_002209923.1 toprim domain-containing protein -
YPD4_RS04630 1031344..1031670 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPD4_RS25115 1031663..1031815 + 153 WP_002209921.1 hypothetical protein -
YPD4_RS04640 1031829..1032029 - 201 WP_002209920.1 AlpA family transcriptional regulator -
YPD4_RS04645 1032211..1032543 - 333 WP_002214791.1 hypothetical protein -
YPD4_RS04650 1032549..1032785 - 237 WP_002214792.1 hypothetical protein -
YPD4_RS04655 1032798..1033163 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T26292 WP_002214787.1 NC_017154:1027659-1027955 [Yersinia pestis D106004]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T26292 NC_017154:1027659-1027955 [Yersinia pestis D106004]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT26292 WP_002209924.1 NC_017154:1027955-1028353 [Yersinia pestis D106004]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT26292 NC_017154:1027955-1028353 [Yersinia pestis D106004]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References