Detailed information of TA system TA262919

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2618999..2619259
• Replicon: chromosome
• Accession: NZ_CP110054
• Organism: Enterococcus faecalis strain BE17

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLL95_RS12800
• Protein ID: WP_075551663.1
• Coordinates: 2619158..2619259 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2618999..2619209 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL95_RS12775 (2614683)	2614683..2615636	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
OLL95_RS12780 (2615675)	2615675..2616430	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OLL95_RS12785 (2616427)	2616427..2617392	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
OLL95_RS12790 (2617389)	2617389..2618336	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
OLL95_RS12795 (2618521)	2618521..2618973	+	453	WP_002354958.1	YueI family protein	-
- (2618999)	2618999..2619209	+	211	NuclAT_3	-	Antitoxin
- (2619036)	2619036..2619213	+	178	NuclAT_9	-	-
OLL95_RS12800 (2619158)	2619158..2619259	-	102	WP_075551663.1	putative holin-like toxin	Toxin
OLL95_RS12805 (2619448)	2619448..2621718	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OLL95_RS12810 (2621889)	2621889..2622389	+	501	WP_002361021.1	cysteine hydrolase family protein	-
OLL95_RS12815 (2622944)	2622944..2623840	+	897	WP_104875316.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T262919 WP_075551663.1 NZ_CP110054:c2619259-2619158 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT262919 NZ_CP110054:2618999-2619209 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin