Detailed information of TA system TA262904

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2513215..2513435
• Replicon: chromosome
• Accession: NZ_CP110053
• Organism: Enterococcus faecalis strain BE25

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLL87_RS12130
• Protein ID: WP_021164441.1
• Coordinates: 2513334..2513435 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2513215..2513389 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLL87_RS12105 (2508862)	2508862..2509815	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
OLL87_RS12110 (2509854)	2509854..2510609	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
OLL87_RS12115 (2510606)	2510606..2511571	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
OLL87_RS12120 (2511568)	2511568..2512515	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
OLL87_RS12125 (2512700)	2512700..2513152	+	453	WP_002354958.1	YueI family protein	-
- (2513178)	2513178..2513385	+	208	NuclAT_3	-	-
- (2513215)	2513215..2513389	+	175	NuclAT_6	-	Antitoxin
OLL87_RS12130 (2513334)	2513334..2513435	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2513610)	2513610..2513819	+	210	NuclAT_4	-	-
- (2513644)	2513644..2513823	+	180	NuclAT_5	-	-
OLL87_RS12135 (2513768)	2513768..2513869	-	102	WP_075551663.1	putative holin-like toxin	-
OLL87_RS12140 (2514060)	2514060..2516330	-	2271	WP_083578756.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
OLL87_RS12145 (2516501)	2516501..2517001	+	501	WP_016634996.1	cysteine hydrolase family protein	-
OLL87_RS12150 (2517400)	2517400..2518296	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	EF3023	2338899..2588841	249942

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T262904 WP_021164441.1 NZ_CP110053:c2513435-2513334 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT262904 NZ_CP110053:2513215-2513389 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin