262864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2647620..2647845 Replicon chromosome
Accession NZ_CP110047
Organism Enterococcus faecalis strain BE33

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag OLL90_RS12870 Protein ID WP_075551663.1
Coordinates 2647744..2647845 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2647620..2647799 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL90_RS12840 2642836..2643789 - 954 WP_264522659.1 siderophore ABC transporter substrate-binding protein -
OLL90_RS12845 2643828..2644583 - 756 WP_002354962.1 ATP-binding cassette domain-containing protein -
OLL90_RS12850 2644580..2645545 - 966 WP_002365351.1 iron chelate uptake ABC transporter family permease subunit -
OLL90_RS12855 2645542..2646489 - 948 WP_002354960.1 iron chelate uptake ABC transporter family permease subunit -
OLL90_RS12860 2646674..2647126 + 453 WP_002354958.1 YueI family protein -
OLL90_RS12865 2647311..2647412 - 102 WP_075551663.1 putative holin-like toxin -
- 2647620..2647799 + 180 - - Antitoxin
OLL90_RS12870 2647744..2647845 - 102 WP_075551663.1 putative holin-like toxin Toxin
OLL90_RS12875 2648034..2650304 - 2271 WP_002354955.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
OLL90_RS12880 2650475..2650975 + 501 WP_002365352.1 cysteine hydrolase family protein -
OLL90_RS12885 2651374..2652270 + 897 WP_002365354.1 YitT family protein -
OLL90_RS12890 2652321..2652719 - 399 WP_002354951.1 glyoxalase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) - 2639894..2688820 48926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-33)


Sequences


Toxin        


Download         Length: 34 a.a.        Molecular weight: 3599.34 Da        Isoelectric Point: 4.5869

>T262864 WP_075551663.1 NZ_CP110047:c2647845-2647744 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Download         Length: 102 bp


Antitoxin


Download         Length: 180 bp

>AT262864 NZ_CP110047:2647620-2647799 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References