262827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 563053..563285 Replicon chromosome
Accession NZ_CP110041
Organism Enterococcus faecalis strain BE43

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag OLM01_RS02885 Protein ID WP_002355568.1
Coordinates 563053..563169 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 563080..563285 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM01_RS02875 558491..560749 + 2259 WP_002363179.1 DNA helicase PcrA -
OLM01_RS02880 560875..562905 + 2031 WP_002355566.1 NAD-dependent DNA ligase LigA -
OLM01_RS02885 563053..563169 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 563080..563285 - 206 - - Antitoxin
OLM01_RS02890 563487..563792 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
OLM01_RS02895 563792..565261 + 1470 WP_002355570.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
OLM01_RS02900 565261..566691 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
OLM01_RS02905 566710..567798 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 567984..568943 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T262827 WP_002355568.1 NZ_CP110041:563053-563169 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT262827 NZ_CP110041:c563285-563080 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References