Detailed information of TA system TA262818

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2576261..2576521
• Replicon: chromosome
• Accession: NZ_CP110040
• Organism: Enterococcus faecalis strain BE45

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLM07_RS12655
• Protein ID: WP_016630771.1
• Coordinates: 2576378..2576521 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2576261..2576445 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM07_RS12640 (2571822)	2571822..2572535	-	714	WP_002354877.1	trehalose operon repressor	-
OLM07_RS12645 (2572797)	2572797..2575541	+	2745	WP_016630773.1	glycosyl hydrolase family 65 protein	-
OLM07_RS12650 (2575556)	2575556..2576206	+	651	WP_016630772.1	beta-phosphoglucomutase	-
- (2576275)	2576275..2576404	+	130	NuclAT_7	-	-
- (2576261)	2576261..2576445	+	185	NuclAT_5	-	Antitoxin
OLM07_RS12655 (2576378)	2576378..2576521	-	144	WP_016630771.1	type I toxin-antitoxin system toxin PepG1	Toxin
OLM07_RS12660 (2576753)	2576753..2577724	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
OLM07_RS12665 (2577899)	2577899..2578336	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
OLM07_RS12670 (2578469)	2578469..2579023	-	555	WP_002354869.1	Maf family protein	-
OLM07_RS12675 (2579048)	2579048..2581090	-	2043	WP_264547450.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5310.47 Da
• Isoelectric Point: 10.8331

>T262818 WP_016630771.1 NZ_CP110040:c2576521-2576378 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYEKIQTILGFGMFTVALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 185 bp

>AT262818 NZ_CP110040:2576261-2576445 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGTGCA
ATCAAAGCAACGGTAAACATACCAA

Structures

Antitoxin