Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 515668..515900 Replicon chromosome
Accession NZ_CP110040
Organism Enterococcus faecalis strain BE45

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag OLM07_RS02565 Protein ID WP_002355568.1
Coordinates 515668..515784 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 515695..515900 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM07_RS02555 (511106) 511106..513364 + 2259 WP_002373397.1 DNA helicase PcrA -
OLM07_RS02560 (513490) 513490..515520 + 2031 WP_002358699.1 NAD-dependent DNA ligase LigA -
OLM07_RS02565 (515668) 515668..515784 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (515695) 515695..515900 - 206 NuclAT_2 - Antitoxin
OLM07_RS02570 (516102) 516102..516407 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
OLM07_RS02575 (516407) 516407..517876 + 1470 WP_016630549.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
OLM07_RS02580 (517876) 517876..519306 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
OLM07_RS02585 (519325) 519325..520413 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T262816 WP_002355568.1 NZ_CP110040:515668-515784 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT262816 NZ_CP110040:c515900-515695 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References