262778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2494207..2494439 Replicon chromosome
Accession NZ_CP110020
Organism Enterococcus faecalis strain BE69

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag OLM05_RS12035 Protein ID WP_002355568.1
Coordinates 2494323..2494439 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2494207..2494412 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM05_RS12015 (2489695) 2489695..2490782 - 1088 Protein_2343 diacylglycerol kinase -
OLM05_RS12020 (2490801) 2490801..2492231 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
OLM05_RS12025 (2492231) 2492231..2493700 - 1470 WP_002419989.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
OLM05_RS12030 (2493700) 2493700..2494005 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- (2494185) 2494185..2494340 + 156 NuclAT_8 - -
- (2494205) 2494205..2494340 + 136 NuclAT_10 - -
- (2494207) 2494207..2494412 + 206 NuclAT_4 - Antitoxin
OLM05_RS12035 (2494323) 2494323..2494439 - 117 WP_002355568.1 putative holin-like toxin Toxin
OLM05_RS12040 (2494587) 2494587..2496620 - 2034 WP_264516823.1 NAD-dependent DNA ligase LigA -
OLM05_RS12045 (2496746) 2496746..2499004 - 2259 WP_002363179.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T262778 WP_002355568.1 NZ_CP110020:c2494439-2494323 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT262778 NZ_CP110020:2494207-2494412 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References