Detailed information of TA system TA262774

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 383140..383520
• Replicon: chromosome
• Accession: NZ_CP110020
• Organism: Enterococcus faecalis strain BE69

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLM05_RS01845
• Protein ID: WP_227330998.1
• Coordinates: 383140..383244 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	383406..383520 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM05_RS01820 (379492)	379492..380046	+	555	WP_002383211.1	nucleoside triphosphate pyrophosphatase	-
OLM05_RS01825 (380179)	380179..380616	+	438	WP_010715474.1	peptide-methionine (R)-S-oxide reductase MsrB	-
OLM05_RS01830 (380791)	380791..381762	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
OLM05_RS01835 (381948)	381948..382349	-	402	WP_002383213.1	hypothetical protein	-
OLM05_RS01840 (382633)	382633..382758	+	126	WP_002383214.1	hypothetical protein	-
- (382846)	382846..382988	-	143	NuclAT_11	-	-
OLM05_RS01845 (383140)	383140..383244	+	105	WP_227330998.1	putative holin-like toxin	Toxin
- (383177)	383177..383364	-	188	NuclAT_5	-	-
- (383406)	383406..383520	-	115	NuclAT_12	-	Antitoxin
OLM05_RS01850 (383549)	383549..384199	-	651	WP_002383215.1	beta-phosphoglucomutase	-
OLM05_RS01855 (384214)	384214..386958	-	2745	WP_002383216.1	glycosyl hydrolase family 65 protein	-
OLM05_RS01860 (387219)	387219..387932	+	714	WP_002354877.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3827.68 Da
• Isoelectric Point: 10.0079

>T262774 WP_227330998.1 NZ_CP110020:383140-383244 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIVLIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 115 bp

>AT262774 NZ_CP110020:c383520-383406 [Enterococcus faecalis]
ACCTCTTTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAAAAAATAACCGTACTCGATCAAAGTTGACGGTT
ATTTTTTATTGTCATTTTTAACAGCTTTTAGGATT

Structures

Antitoxin