Detailed information of TA system TA262768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2495591..2495815
• Replicon: chromosome
• Accession: NZ_CP110019
• Organism: Enterococcus faecalis strain BE70

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: OLM00_RS12105
• Protein ID: WP_227330998.1
• Coordinates: 2495711..2495815 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2495591..2495778 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OLM00_RS12090 (2491023)	2491023..2491736	-	714	WP_002354877.1	trehalose operon repressor	-
OLM00_RS12095 (2491997)	2491997..2494741	+	2745	WP_002383216.1	glycosyl hydrolase family 65 protein	-
OLM00_RS12100 (2494756)	2494756..2495406	+	651	WP_002383215.1	beta-phosphoglucomutase	-
- (2495435)	2495435..2495549	+	115	NuclAT_12	-	-
- (2495591)	2495591..2495778	+	188	NuclAT_5	-	Antitoxin
OLM00_RS12105 (2495711)	2495711..2495815	-	105	WP_227330998.1	putative holin-like toxin	Toxin
- (2495967)	2495967..2496109	+	143	NuclAT_11	-	-
OLM00_RS12110 (2496197)	2496197..2496322	-	126	WP_002383214.1	hypothetical protein	-
OLM00_RS12115 (2496606)	2496606..2497139	+	534	WP_002416003.1	CPBP family intramembrane metalloprotease	-
OLM00_RS12120 (2497192)	2497192..2498163	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
OLM00_RS12125 (2498338)	2498338..2498775	-	438	WP_010715474.1	peptide-methionine (R)-S-oxide reductase MsrB	-
OLM00_RS12130 (2498908)	2498908..2499463	-	556	Protein_2357	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3827.68 Da
• Isoelectric Point: 10.0079

>T262768 WP_227330998.1 NZ_CP110019:c2495815-2495711 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIVLIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 188 bp

>AT262768 NZ_CP110019:2495591-2495778 [Enterococcus faecalis]
TGTGCTATAATAAAAATGAAAAGAGAGACATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGC
ACAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin