Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3264967..3265660 Replicon chromosome
Accession NZ_CP110018
Organism Escherichia coli strain DH10B

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag OLR78_RS16080 Protein ID WP_000415584.1
Coordinates 3265364..3265660 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OLR78_RS16075 Protein ID WP_000650107.1
Coordinates 3264967..3265362 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR78_RS16065 (3260831) 3260831..3263089 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
OLR78_RS16070 (3263227) 3263227..3264834 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OLR78_RS16075 (3264967) 3264967..3265362 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OLR78_RS16080 (3265364) 3265364..3265660 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
OLR78_RS16085 (3265865) 3265865..3266347 - 483 WP_000183505.1 GyrI-like domain-containing protein -
OLR78_RS16090 (3266400) 3266400..3266792 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OLR78_RS16095 (3266944) 3266944..3267603 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
OLR78_RS16100 (3267600) 3267600..3268949 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
OLR78_RS16105 (3268995) 3268995..3269327 - 333 WP_000917684.1 DUF2645 family protein -
OLR78_RS16110 (3269646) 3269646..3270227 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OLR78_RS16115 (3270258) 3270258..3270572 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T262756 WP_000415584.1 NZ_CP110018:c3265660-3265364 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262756 WP_000650107.1 NZ_CP110018:c3265362-3264967 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References