Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3264963..3265656 Replicon chromosome
Accession NZ_CP110017
Organism Escherichia coli strain HE_50

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag OLR76_RS16080 Protein ID WP_282983233.1
Coordinates 3265360..3265656 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OLR76_RS16075 Protein ID WP_000650107.1
Coordinates 3264963..3265358 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR76_RS16065 (3260827) 3260827..3263085 - 2259 WP_255784241.1 DNA topoisomerase IV subunit A -
OLR76_RS16070 (3263223) 3263223..3264830 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OLR76_RS16075 (3264963) 3264963..3265358 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OLR76_RS16080 (3265360) 3265360..3265656 - 297 WP_282983233.1 type II toxin-antitoxin system toxin MqsR Toxin
OLR76_RS16085 (3265861) 3265861..3266343 - 483 WP_000183505.1 GyrI-like domain-containing protein -
OLR76_RS16090 (3266396) 3266396..3266788 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OLR76_RS16095 (3266940) 3266940..3267599 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
OLR76_RS16100 (3267596) 3267596..3268945 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
OLR76_RS16105 (3268991) 3268991..3269323 - 333 WP_000917684.1 DUF2645 family protein -
OLR76_RS16110 (3269642) 3269642..3270223 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OLR76_RS16115 (3270254) 3270254..3270568 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11245.99 Da        Isoelectric Point: 8.9070

>T262730 WP_282983233.1 NZ_CP110017:c3265656-3265360 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSEHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262730 WP_000650107.1 NZ_CP110017:c3265358-3264963 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References