262699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2178226..2178728 Replicon chromosome
Accession NZ_CP110016
Organism Escherichia coli strain HE_100

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag OLR74_RS10935 Protein ID WP_000767829.1
Coordinates 2178226..2178480 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag OLR74_RS10940 Protein ID WP_001259255.1
Coordinates 2178477..2178728 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR74_RS10905 (2173241) 2173241..2173468 - 228 WP_000234896.1 sulfurtransferase TusA -
OLR74_RS10910 (2173482) 2173482..2174540 - 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
OLR74_RS10915 (2174719) 2174719..2176077 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
OLR74_RS10920 (2176067) 2176067..2176129 - 63 WP_010723108.1 membrane protein YoeI -
OLR74_RS10925 (2176344) 2176344..2177273 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
OLR74_RS10930 (2177319) 2177319..2178143 - 825 WP_000754737.1 SDR family oxidoreductase -
OLR74_RS10935 (2178226) 2178226..2178480 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
OLR74_RS10940 (2178477) 2178477..2178728 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
OLR74_RS10945 (2179011) 2179011..2179061 + 51 WP_001364200.1 his operon leader peptide -
OLR74_RS10950 (2179207) 2179207..2180106 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
OLR74_RS10955 (2180112) 2180112..2181416 + 1305 WP_000009594.1 histidinol dehydrogenase -
OLR74_RS10960 (2181413) 2181413..2182483 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
OLR74_RS10965 (2182483) 2182483..2183550 + 1068 WP_282983576.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T262699 WP_000767829.1 NZ_CP110016:c2178480-2178226 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT262699 WP_001259255.1 NZ_CP110016:c2178728-2178477 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References