262678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3264962..3265655 Replicon chromosome
Accession NZ_CP110015
Organism Escherichia coli strain HE_150

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag OLR73_RS16075 Protein ID WP_282983233.1
Coordinates 3265359..3265655 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag OLR73_RS16070 Protein ID WP_000650107.1
Coordinates 3264962..3265357 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLR73_RS16060 (3260826) 3260826..3263084 - 2259 WP_255784241.1 DNA topoisomerase IV subunit A -
OLR73_RS16065 (3263222) 3263222..3264829 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
OLR73_RS16070 (3264962) 3264962..3265357 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
OLR73_RS16075 (3265359) 3265359..3265655 - 297 WP_282983233.1 type II toxin-antitoxin system toxin MqsR Toxin
OLR73_RS16080 (3265860) 3265860..3266342 - 483 WP_000183505.1 GyrI-like domain-containing protein -
OLR73_RS16085 (3266395) 3266395..3266787 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
OLR73_RS16090 (3266939) 3266939..3267598 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
OLR73_RS16095 (3267595) 3267595..3268944 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
OLR73_RS16100 (3268990) 3268990..3269322 - 333 WP_000917684.1 DUF2645 family protein -
OLR73_RS16105 (3269641) 3269641..3270222 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
OLR73_RS16110 (3270253) 3270253..3270567 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11245.99 Da        Isoelectric Point: 8.9070

>T262678 WP_282983233.1 NZ_CP110015:c3265655-3265359 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSEHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT262678 WP_000650107.1 NZ_CP110015:c3265357-3264962 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References