Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3979529..3980126 Replicon chromosome
Accession NZ_CP109983
Organism Klebsiella pneumoniae strain KP424

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag OJ961_RS19225 Protein ID WP_004142563.1
Coordinates 3979809..3980126 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OJ961_RS19220 Protein ID WP_004142561.1
Coordinates 3979529..3979816 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OJ961_RS19190 (3975609) 3975609..3975857 + 249 WP_020325243.1 DUF1158 domain-containing protein -
OJ961_RS19195 (3975875) 3975875..3976216 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OJ961_RS19200 (3976247) 3976247..3977362 - 1116 WP_020325248.1 MBL fold metallo-hydrolase -
OJ961_RS19205 (3977542) 3977542..3978123 + 582 WP_020325240.1 TetR/AcrR family transcriptional regulator -
OJ961_RS19210 (3978123) 3978123..3978491 + 369 WP_020325252.1 MmcQ/YjbR family DNA-binding protein -
OJ961_RS19215 (3978611) 3978611..3979264 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
OJ961_RS19220 (3979529) 3979529..3979816 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OJ961_RS19225 (3979809) 3979809..3980126 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OJ961_RS19230 (3980311) 3980311..3981354 - 1044 WP_020325241.1 DUF2157 domain-containing protein -
OJ961_RS19235 (3982023) 3982023..3982889 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
OJ961_RS19240 (3982998) 3982998..3984425 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T262611 WP_004142563.1 NZ_CP109983:c3980126-3979809 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT262611 WP_004142561.1 NZ_CP109983:c3979816-3979529 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References