Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2791610..2792346 | Replicon | chromosome |
| Accession | NZ_CP109965 | ||
| Organism | Catenovulum sp. TS8 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | OLW01_RS12295 | Protein ID | WP_268074208.1 |
| Coordinates | 2792035..2792346 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OLW01_RS12290 | Protein ID | WP_268074207.1 |
| Coordinates | 2791610..2792038 (-) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OLW01_RS12255 (OLW01_12255) | 2787503..2787889 | - | 387 | WP_268074201.1 | MerC domain-containing protein | - |
| OLW01_RS12260 (OLW01_12260) | 2788102..2788554 | - | 453 | WP_268074202.1 | 50S ribosomal protein L9 | - |
| OLW01_RS12265 (OLW01_12265) | 2788589..2788816 | - | 228 | WP_017443714.1 | 30S ribosomal protein S18 | - |
| OLW01_RS12270 (OLW01_12270) | 2788827..2789135 | - | 309 | WP_268074203.1 | primosomal replication protein N | - |
| OLW01_RS12275 (OLW01_12275) | 2789138..2789524 | - | 387 | WP_268074204.1 | 30S ribosomal protein S6 | - |
| OLW01_RS12280 (OLW01_12280) | 2789771..2790409 | + | 639 | WP_268074205.1 | fused MFS/spermidine synthase | - |
| OLW01_RS12285 (OLW01_12285) | 2790426..2791301 | + | 876 | WP_268074206.1 | fused MFS/spermidine synthase | - |
| OLW01_RS12290 (OLW01_12290) | 2791610..2792038 | - | 429 | WP_268074207.1 | transcriptional regulator | Antitoxin |
| OLW01_RS12295 (OLW01_12295) | 2792035..2792346 | - | 312 | WP_268074208.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OLW01_RS12300 (OLW01_12300) | 2792573..2792893 | + | 321 | WP_268074209.1 | hypothetical protein | - |
| OLW01_RS12305 (OLW01_12305) | 2793114..2793365 | - | 252 | WP_268074210.1 | hypothetical protein | - |
| OLW01_RS12310 (OLW01_12310) | 2793621..2794502 | - | 882 | WP_268074211.1 | hypothetical protein | - |
| OLW01_RS12315 (OLW01_12315) | 2795205..2795519 | - | 315 | WP_268074212.1 | peptidylprolyl isomerase | - |
| OLW01_RS12320 (OLW01_12320) | 2795606..2796922 | - | 1317 | WP_268074213.1 | adenylosuccinate synthase | - |
| OLW01_RS12325 (OLW01_12325) | 2797118..2797294 | - | 177 | WP_268074214.1 | DUF2065 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12200.06 Da Isoelectric Point: 9.8146
>T262570 WP_268074208.1 NZ_CP109965:c2792346-2792035 [Catenovulum sp. TS8]
MHVISRKPFSDAAKKYPNDAAAIDALYKSLKNNNFSNPLEMKNFYPSLDNFKYKDKWYVLDIGGNNLRLMTFIEFRDNRM
FVKYIVPHAEYDKLCTKYAKESK
MHVISRKPFSDAAKKYPNDAAAIDALYKSLKNNNFSNPLEMKNFYPSLDNFKYKDKWYVLDIGGNNLRLMTFIEFRDNRM
FVKYIVPHAEYDKLCTKYAKESK
Download Length: 312 bp
Antitoxin
Download Length: 143 a.a. Molecular weight: 16116.39 Da Isoelectric Point: 4.3332
>AT262570 WP_268074207.1 NZ_CP109965:c2792038-2791610 [Catenovulum sp. TS8]
MKNFNQIKSTALQLFSMASFVSHISTEEEYTEALALMEDLIKEYDIYKPLIEVLEVSIERWEDSADEFAEFNARIENLDD
GVATLRVLIDQYQLKADDLKDVIGGKSLVSMILNGSRKLTKEHIQAISSKYNISPALFFGCV
MKNFNQIKSTALQLFSMASFVSHISTEEEYTEALALMEDLIKEYDIYKPLIEVLEVSIERWEDSADEFAEFNARIENLDD
GVATLRVLIDQYQLKADDLKDVIGGKSLVSMILNGSRKLTKEHIQAISSKYNISPALFFGCV
Download Length: 429 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|